' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 25 Reviews
8.5
Supplement Facts
Serving Size: 1 Veggie Softgel
Amount Per Serving
%DV
Coenzyme Q10 (Ubiquinone)
300 mg
†
Black Pepper Ext. (Piper nigrum)(fruit)(standardized to contain 95% Piperine)(BioPerine®)
5 mg
†
Top Medical Research Studies
9
Coenzyme Q10 aids heart recovery
Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome.
Highly relevant study findings
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Read More
9
CoQ10 reduces heart cell death
Cardioprotective Effect of Coenzyme Q on Apoptotic Myocardial Cell Death by Regulation of Bcl-2 Gene Expression.
Highly relevant to heart attack treatments.
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
Read More
8
CoQ10 improves heart recovery post-MI
Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway.
Direct investigation of CoQ10 benefits
We embarked on a study to explore how Coenzyme Q10 (CoQ10) might aid in recovering cardiac function following a heart attack, or myocardial infarction (MI). By measuring the effects of CoQ10 on both patients and mice, we aimed to understand its role in promoting heart health post-MI.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Our research included a comparison between MI patients receiving CoQ10 and those who did not. We conducted evaluations at one and three months after treatments to assess heart function. In the animal model, we observed that mice receiving CoQ10 showed improved heart performance compared to those that did not, suggesting significant benefits for heart recovery.
An interesting finding was that CoQ10 appears to inhibit certain inflammatory responses in the heart, specifically by affecting a pathway associated with macrophages, which are immune cells that can contribute to inflammation. By preventing these macrophages from accumulating in the heart and activating pro-inflammatory signals, CoQ10 may help to reduce the harmful effects of inflammation following a heart attack.
Overall, our results indicate that CoQ10 can be a valuable addition to treatment plans for individuals recovering from heart attacks, potentially speeding up recovery and improving heart function.
Read More
Most Useful Reviews
9.5
Highly recommended
My cardiologist advised me to take 300 mg of Q10 daily. This product is excellent quality and reasonably priced compared to similar items in Israel. I recommend always getting essential supplements from this site.
Read More
9.5
Improved heart health
I've been taking Doctor's Best High Absorption CoQ10 for a few months, and I've felt a fantastic improvement in my energy levels and heart health. The 300 mg dosage with BioPerine® enhances absorption, ensuring I receive the maximum benefits. These veggie softgels are easy to swallow and free from artificial additives, which I value. I've noticed reduced muscle fatigue after exercise and feel stronger overall. I highly recommend Doctor's Best for anyone seeking a potent, absorbable CoQ10 supplement at a great price.
Read More
9.5
Supports heart function
Excellent coenzyme with black pepper extract for enhanced absorption and a good price/quality ratio. A fundamental supplement for those over 40, CoQ10 helps produce energy and strengthens heart function while combating free radicals and oxidative stress. It's also beneficial for skin health. Take with meals for optimal absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
9
Coenzyme Q10 mitigates heart attack effects
Therapeutic effect of coenzyme-Q10 pretreatment on isoprenaline-induced cardiogenic hepatorenal complications in rats.
Direct evaluation in animal model
We explored the connection between acute heart attacks and potential liver and kidney complications, specifically focusing on the role of coenzyme Q10 (Q10). In our study, we examined male rats divided into groups—some receiving normal saline and others pretreated with Q10 for 28 days, followed by an induced heart attack using isoprenaline (ISO).
Our findings revealed that ISO administration increased oxidative stress and negatively affected liver and kidney health. However, those pretreated with Q10 showed notable protection against both biochemical and tissue changes linked to these complications. We observed significantly improved antioxidant levels and a reduction in harmful liver and kidney enzymes. Furthermore, the histopathological examination indicated less severe damage in the tissues of the rats given Q10 compared to those that received ISO alone.
Overall, this study suggests that coenzyme Q10 may help shield the liver and kidneys during recovery from a heart attack by counteracting oxidative stress and reducing fibrotic changes. This finding highlights the potential of Q10 as a supportive treatment during critical cardiac events.
Our findings revealed that ISO administration increased oxidative stress and negatively affected liver and kidney health. However, those pretreated with Q10 showed notable protection against both biochemical and tissue changes linked to these complications. We observed significantly improved antioxidant levels and a reduction in harmful liver and kidney enzymes. Furthermore, the histopathological examination indicated less severe damage in the tissues of the rats given Q10 compared to those that received ISO alone.
Overall, this study suggests that coenzyme Q10 may help shield the liver and kidneys during recovery from a heart attack by counteracting oxidative stress and reducing fibrotic changes. This finding highlights the potential of Q10 as a supportive treatment during critical cardiac events.
Read More
9
CoQ10 offers protection post-MI
Synergetic EGCG and coenzyme Q10 DSPC liposome nanoparticles protect against myocardial infarction.
Effectively combines two agents
We explored the effectiveness of coenzyme Q10 (CoQ10) when used alongside epigallocatechin gallate (EGCG) in protecting heart cells after a myocardial infarction (MI). The study focused on liposome nanoparticles made with distearyl phosphatidylcholine (DSPC) to deliver these compounds effectively. By doing this, we aimed to see whether this combination could reduce oxidative stress and cell death in heart tissue.
Our results showed that these liposome nanoparticles, referred to as CE-LNPs, were well-tolerated by cells and were taken up efficiently by macrophages. These nanoparticles successfully lowered harmful reactive oxygen species (ROS) in heart cells under stress, lessened cell death, and helped maintain the health and growth of those cells. We validated these positive outcomes through various tests that confirm their anti-apoptotic properties, or their ability to prevent cell death.
In a mouse model of MI, the CE-LNPs significantly reduced scar tissue formation, aiding in cardiac recovery and enhancing heart function. These findings suggest that using CoQ10 in conjunction with EGCG within DSPC liposomes can provide protective effects against heart damage following a heart attack. However, since these two were tested together, we note that isolating the specific impact of CoQ10 alone remains challenging. Overall, we have evidence of a promising approach for heart protection using these formulations.
Our results showed that these liposome nanoparticles, referred to as CE-LNPs, were well-tolerated by cells and were taken up efficiently by macrophages. These nanoparticles successfully lowered harmful reactive oxygen species (ROS) in heart cells under stress, lessened cell death, and helped maintain the health and growth of those cells. We validated these positive outcomes through various tests that confirm their anti-apoptotic properties, or their ability to prevent cell death.
In a mouse model of MI, the CE-LNPs significantly reduced scar tissue formation, aiding in cardiac recovery and enhancing heart function. These findings suggest that using CoQ10 in conjunction with EGCG within DSPC liposomes can provide protective effects against heart damage following a heart attack. However, since these two were tested together, we note that isolating the specific impact of CoQ10 alone remains challenging. Overall, we have evidence of a promising approach for heart protection using these formulations.
Read More
9
Coenzyme Q10 aids heart recovery
Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome.
Highly relevant study findings
We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.
Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.
Read More
9
CoQ10 reduces heart cell death
Cardioprotective Effect of Coenzyme Q on Apoptotic Myocardial Cell Death by Regulation of Bcl-2 Gene Expression.
Highly relevant to heart attack treatments.
We explored how coenzyme Q10 (CoQ10) impacts heart damage caused by a lack of blood flow, known as ischemia, followed by the restoration of blood flow, which can lead to further injury. In our study, we utilized a rat model divided into three groups: a control group that did not undergo any induced heart injury, a group that experienced ischemia and reperfusion, and a group pre-treated with CoQ10 before the injury.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
The results indicated that CoQ10 treatment significantly reduced signs of myocardial cell death, often associated with heart attacks. Specifically, we observed a decrease in apoptotic DNA, which is a marker of cell death, and an increase in the production of nitric oxide, a vital molecule for heart health. This suggests that CoQ10 not only helps combat oxidative stress but also enhances the heart's resilience against damage caused during ischemia and subsequent reperfusion.
Overall, our findings align with previous research highlighting CoQ10's potential to protect heart tissue during critical injury phases. By regulating gene expression linked to cell survival, CoQ10 appears to offer a protective effect that could be valuable in heart attack treatments.
Read More
8
Coenzyme Q10 may aid heart recovery
Angiotensin converting enzyme inhibitor and coenzyme Q10 as adjunctive treatment for patients with ventricular septal rupture following late onset myocardial infarction: a case report.
Limited isolated effect evidence
We explored the effects of coenzyme Q10 in conjunction with lisinopril as a treatment for patients suffering from ventricular septal rupture (VSR) following a heart attack. This rare complication can lead to severe issues and is typically treated with surgery. However, not all hospitals have the facilities for immediate surgical intervention, making alternative treatments essential.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
In a recent case, a 74-year-old woman was admitted with late-onset myocardial infarction and subsequently diagnosed with VSR and pulmonary hypertension. As her condition worsened, traditional treatment with vasopressors was initiated. To enhance her recovery, doctors introduced lisinopril and coenzyme Q10, which reportedly supported her heart function and stability over three months.
While the findings suggest that the combination of these two treatments could improve energy production and tissue healing, it is crucial to note the difficulty in isolating the effects of coenzyme Q10 alone from lisinopril. This limitation makes it hard to draw definitive conclusions about how effective coenzyme Q10 is on its own for managing heart attack complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.5
9.5
Symptom relief
I previously took 100 mg but switched to 300 mg. After over six months, my heart used to beat irregularly, but those symptoms have disappeared completely.
9.5
Heart health boost
I've been taking this for four years and had a recent heart check-up which confirmed I have a healthy heart. I had surgery eight years ago, and now I feel great, thanks to these large, soft capsules that are easy to swallow.
9.5
Highly recommended
My cardiologist advised me to take 300 mg of Q10 daily. This product is excellent quality and reasonably priced compared to similar items in Israel. I recommend always getting essential supplements from this site.
9.5
Improved heart health
I've been taking Doctor's Best High Absorption CoQ10 for a few months, and I've felt a fantastic improvement in my energy levels and heart health. The 300 mg dosage with BioPerine® enhances absorption, ensuring I receive the maximum benefits. These veggie softgels are easy to swallow and free from artificial additives, which I value. I've noticed reduced muscle fatigue after exercise and feel stronger overall. I highly recommend Doctor's Best for anyone seeking a potent, absorbable CoQ10 supplement at a great price.
Read More
9.5
Supports heart function
Excellent coenzyme with black pepper extract for enhanced absorption and a good price/quality ratio. A fundamental supplement for those over 40, CoQ10 helps produce energy and strengthens heart function while combating free radicals and oxidative stress. It's also beneficial for skin health. Take with meals for optimal absorption.
Read More
